Santoli from a T - ALL sample engrafted in SCID mice
نویسندگان
چکیده
http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
منابع مشابه
Establishment of a karyotypically normal cytotoxic leukemic T-cell line from a T-ALL sample engrafted in SCID mice.
Bone marrow (BM) cells from a child with an immature (CD3-) acute T lymphoblastic leukemia (T-ALL) bearing no chromosomal abnormalities failed to grow in long-term culture in the presence or absence of recombinant human (rh) growth factors but could be engrafted in severe combined immunodeficient (SCID) mice and induced leukemia. The leukemic cells recovered from the animal tissues could be ada...
متن کاملHoming and progression patterns of childhood acute lymphoblastic leukemias in severe combined immunodeficiency mice.
The aim of this study was to analyze the homing and progression patterns of childhood acute lymphoblastic leukemias (ALL) in mice with severe combined immunodeficiency (SCID). Upon intraperitoneal (IP) transfer, cells from relapse samples of three children with T-lineage ALL spread hematogenously and infiltrated the non-lymphoid and/or lymphoid organs with a pattern reminiscent of the human cli...
متن کاملLimits of the Human-PBL-SCID Mice Model: Severe Restriction of the Vb T-Cell Repertoire of Engrafted Human T Cells
A recent study in the human-peripheral blood lymphocytesrepertoire were associated with a severe restriction in both severe combined immunodeficiency (hu-PBL-SCID) model, the CDR3 size distribution pattern of the Vb transcripts and analyzing the specificity of the engrafted human T cells, the number of Jb segments used by these transcripts. In showed that human T-cell lines and clones derived f...
متن کاملLimits of the human-PBL-SCID mice model: severe restriction of the V beta T-cell repertoire of engrafted human T cells.
A recent study in the human-peripheral blood lymphocytes severe combined immunodeficiency (hu-PBL-SCID) model, analyzing the specificity of the engrafted human T cells, showed that human T-cell lines and clones derived from engrafted cells presented a xenoreactivity toward murine host molecules. This observation raised the question of the influence of the SCID environment on the ex vivo reperto...
متن کاملGeneration of intestinal mucosal lymphocytes in SCID mice reconstituted with mature, thymus-derived T cells.
Transfer of peripheral lymph node lymphocytes to SCID mice leads to the long term establishment of mucosal T lymphocytes within the epithelium and lamina propria of the small and large intestines. Analysis of engrafted intraepithelial lymphocytes (IEL) showed that they had acquired a surface phenotype that in several respects is typical of IEL. In addition, the functional profile of engrafted I...
متن کامل